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Acute Vascular Response to Exercise in Women With Nonobstructive Coronary Artery Disease

September 11, 2019

Overview

The Acute Vascular Response to Exercise in Women With Nonobstructive Coronary Artery Disease study aims to research how exercise affects women with CAD. Subjects will be monitored after walking on a treadmill at a slow pace for 47 minutes.

 

Study Information

In the study, subjects will be measured for dilation, arterial stiffness, and wave reflection to see if walking on a treadmill for 47 minutes at a slow pace affects them. The measurements will be done with brachial artery flow-mediated dilation via high resolution ultrasonography, sublingual nitroglycerin, and applanation tonometry. This is an interventional clinical trial with an estimated 75 participants in a single group assignment.

 

Inclusion Criteria

  • Women with non-obstructive coronary artery disease documented by coronary angiogram
  • Ages 18-89

 

Exclusion Criteria

  • Use of tobacco products
  • Use of oral contraceptives or hormone replacement therapy
  • Pregnancy (positive urine pregnancy test) or lactation
  • History of hepatic disease or infection with hepatitis B, C or HIV

 

Location

Integrative Cardiovascular Physiology Laboratory

Gainesville, Florida, United States, 32611

Contact: Demetra Christou, PhD    352-294-1746 ICPL@hhp.ufl.edu   

 

Collaborators/Sponsors

University of Florida

Principal Investigator: Demetra Christou, PhD, University of Florida

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